acetamidozole 2-acetamido-5-nitrothiazole

structural formula

• numbering system
• physical property data
• toxicological data
• ecological data
• molecular structure data
• computing chemical data
• more
  • properties and stability
  • storage method
  • synthesis method
  • purpose

numbering system

cas number:140-40-9

mdl number:mfcd00022438

einecs number:205-414-7

rtecs number:xj1570000

brn number:none

pubchem id:none

physical property data

1. physical property data

1.characteristics: white crystalline powder, slightly odorous, almost tasteless

2.melting point (℃): 264～266℃(decomposes ).

3.solubility: in sodium hydroxide(potassium)lye and ammonia moderately soluble, soluble in ethanol, slightly soluble in chloroform, slightly soluble in ether, almost insoluble in water

toxicological data

2. toxicological data:

1, acute toxicity: rat abdominal cavity ld50: >200 mg/kg;

rat orally ld50 ：>400 mg/kg;

rat subcutaneous ld: >3200 mg/kg;

orally administered to mice ld50 ：200 mg/kg;

mouse abdominal cavity ld50: >300 mg/kg;

mouse subcutaneous ld: >3200 mg/kg.

ecological data

3. ecological data:

1, other harmful effects: this substance may be harmful to the environment, special attention should be paid to water bodies.

molecular structure data

5. molecular property data:

1. molar refractive index:43.54

2. molar volume (m³/ mol):117.0

3. isotonic specific volume (90.2k): 343.8

4. surface tension (dyne/cm): 74.4

5. polarizability（10^-24cm³):17.26

compute chemical data

1. reference value for hydrophobic parameter calculation (xlogp): none

2. number of hydrogen bond donors: 1

3. number of hydrogen bond acceptors: 5

4. number of rotatable chemical bonds: 1

5. number of tautomers: 5

6. topological molecule polar surface area 116

7. number of heavy atoms: 12

8. surface charge: 0

9. complexity: 205

10. number of isotope atoms: 0

11. determine the number of atomic stereocenters: 0

12. uncertain number of atomic stereocenters: 0

13. determine the number of chemical bond stereocenters: 0

14. number of uncertain chemical bond stereocenters: 0

15. number of covalent bond units: 1

properties and stability

stable under normal temperature and pressure.

storage method

stored sealed in a dry and cool place.

synthesis method

by2-aminothiazole is used as raw material.

purpose

3. isotonic specific volume (90.2k):343.8

4. surface tension (dyne/cm): 74.4

5. polarizability（10^-24cm³):17.26

compute chemical data

1. reference value for hydrophobic parameter calculation (xlogp): none

2. number of hydrogen bond donors: 1

3. number of hydrogen bond acceptors: 5

4. number of rotatable chemical bonds: 1

5. number of tautomers: 5

6. topological molecule polar surface area 116

7. number of heavy atoms: 12

8. surface charge: 0

9. complexity: 205

10. number of isotope atoms: 0

11. determine the number of atomic stereocenters: 0

12. uncertain number of atomic stereocenters: 0

13. determine the number of chemical bond stereocenters: 0

14. number of uncertain chemical bond stereocenters: 0

15. number of covalent bond units: 1

properties and stability

stable under normal temperature and pressure.

storage method

stored sealed in a dry and cool place.

synthesis method

by2-aminothiazole is used as raw material.

purpose

it is suitable for oral treatment of trichomoniasis, and can also be used for the treatment of amoebic and intestinal bacterial infections.

tyle=”font-size: 10pt; color: #333333; font-family: 宋体; mso-ascii-font-family: ‘times new roman’; mso-hansi-font-family: ‘times new roman'”>applicable it is used for the oral treatment of trichomoniasis and can also be used to treat amoebic and intestinal bacterial infections.