furosemide furosemide

structural formula

• numbering system
• physical property data
• toxicological data
• ecological data
• molecular structure data
• computing chemical data
• more
  • properties and stability
  • storage method
  • synthesis method
  • purpose

numbering system

cas number:54-31-9

mdl number:mfcd00010549

einecs number:200-203-6

rtecs number:cb2625000

brn number:none

pubchem number:24277714

physical property data

1. character:white or off-white crystalline powder, odorless, almost tasteless.

2. density (g/ml,25/4℃): undetermined

3. relative vapor density (g/ml,air=1): undetermined

4. melting point (ºc): 206

5. boiling point (ºc,normal pressure): undetermined

6. boiling point (ºc,5.2kpa): undetermined

7. refractive index: undetermined

8. flashpoint (ºc): undetermined

9. specific optical rotation (º): undetermined

10. autoignition point or ignition temperature (ºc): undetermined

11. vapor pressure (kpa,25ºc): undetermined

molar volume (m³/mol ): 205.8

3. isotonic specific volume (90.2k):606.2

4. surface tension (dyne/cm):75.2

5. polarizability（10^-24cm³):30.03

compute chemical data

1. reference value for hydrophobic parameter calculation (xlogp): none

2. number of hydrogen bond donors: 3

3. number of hydrogen bond acceptors: 7

4. number of rotatable chemical bonds: 5

5. number of tautomers: 4

6. topological molecule polar surface area 131

7. number of heavy atoms: 21

8. surface charge: 0

9. complexity: 481

10. number of isotope atoms: 0

11. determine the number of atomic stereocenters: 0

12. uncertain number of atomic stereocenters: 0

13. determine the number of chemical bond stereocenters: 0

14. number of uncertain chemical bond stereocenters: 0

15. number of covalent bond units: 1

properties and stability

none

storage method

this product should be sealed and stored in a cool, dry place.

synthesis method

by 2, 4-dichlorobenzoic acid (see 12740) undergoes chlorosulfonation, amination, and acidification to obtain 2, 4-dichloro-5-sulfamoylbenzoic acid. it is then condensed with furfurylamine to produce furosemide.

purpose

this product has a strong but short-lived diuretic effect. it is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.

amily: 宋体”>from 2, 4- dichlorobenzoic acid (see 12740) through chlorosulfonation, ammoniation and acidification to obtain 2, 4-dichloro-5-sulfamoyl benzoic acid. it is then condensed with furfurylamine to produce furosemide.

purpose

this product has a strong but short-lived diuretic effect. it is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.