methotrexate methotrexate

structural formula

• numbering system
• physical property data
• toxicological data
• ecological data
• molecular structure data
• computing chemical data
• more
  • properties and stability
  • storage method
  • synthesis method
  • purpose

numbering system

cas number:59-05-2

mdl number:mfcd00064370

einecs number:200-413-8

rtecs number:ma1225000

brn number:70669

pubchem number:24897373

physical property data

1. characteristics: yellow crystal. odorless.

2. density (g/ml,25/4℃): undetermined

3. relative vapor density (g/ml,air=1): undetermined

4. melting point (ºc): undetermined

5. boiling point (ºc,normal pressure): undetermined

6. boiling point (ºc,5.2kpa): undetermined

7. refractive index: undetermined

8. flashpoint (ºc): undetermined

9. specific optical rotation (º): span>undetermined

10. autoignition point or ignition temperature (ºc): undetermined

11. vapor pressure (kpa,25ºc9. complexity: 704

10. number of isotope atoms: 0

11. determine the number of atomic stereocenters: 1

12. the number of uncertain atomic stereocenters: 0

13. determine the number of stereocenters of chemical bonds: 0

14. uncertain number of chemical bond stereocenters: 0

15. number of covalent bond units: 1

properties and stability

none yet

storage method

sealing4store dry at ℃.

synthesis method

by2,4,5,6- it is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.

purpose

folic acid antagonizes liu. a potent inhibitor of dihydrofolate reductase. immunosuppressants. tissue culture reagents.

this product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. oral methotrexate12hafter the original drug90%excreted in urine, the main metabolite is7-hydroxymethotrexate. intravenous injection in ratsld50 for14mg/kg.

font-family: arial; mso-bidi-font-family: arial; mso-font-kerning: 0pt”>,4,5,6-it is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.

purpose

folic acid antagonizes liu. a potent inhibitor of dihydrofolate reductase. immunosuppressants. tissue culture reagents.

this product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. oral methotrexate12hafter the original drug90%excreted in urine, the main metabolite is7-hydroxymethotrexate. intravenous injection in ratsld50 for14mg/kg.