lidocaine

structural formula

• numbering system
• physical property data
• toxicological data
• ecological data
• molecular structure data
• computing chemical data
• more
  • properties and stability
  • storage method
  • synthesis method
  • purpose

numbering system

cas number:137-58-6

mdl number:mfcd00026733

einecs number:205-302-8

rtecs number:an7525000

brn number:none

pubchem number:24896480

physical property data

1. appearance: white crystalline powder

2. melting point (℃): 76~79

3. solubility: easily soluble in water or ethanol, soluble in chloroform , insoluble in ether.

toxicological data

none

ecological data

none

molecular structure data

1. molar refractive index: 72.42

2. molar volume (cm³/mol): 228.3

3. isotonic specific volume (90.2k): 571.1

4. surface tension (3.0 dyne/cm): 39.1

5. polarizability (0.5 10^-24cm³): 28.71

compute chemical data

1. reference value for hydrophobic parameter calculation (xlogp): none

2. number of hydrogen bond donors: 1

3. number of hydrogen bond acceptors: 2

4. number of rotatable chemical bonds: 5

5. number of tautomers: 3

6. topological molecule polar surface area 32.3

7. number of heavy atoms: 17

8. surface charge: 0

9. complexity: 228

10. number of isotope atoms: 0

11. determine the number of atomic stereocenters: 0

12. uncertain number of atomic stereocenters: 0

13. determine the number of chemical bond stereocenters: 0

14. number of uncertain chemical bond stereocenters: 0

15. number of covalent bond units: 1

properties and stability

none

storage method

this product should be sealed and stored in a cool, dry place.

synthesis method

1. chloroacetyl chloride method

2,6-dimethylaniline undergoes chloroacetylation with chloroacetyl chloride, then condenses with diethylamine, and then acidifies to form a salt to obtain lidocaine.

2. diethylaminoacetic acid methyl ester method

in the presence of sodium methoxide, 2,6-dimethylaniline and n,n-diethylaminoacetic acid methyl ester are condensed, it is then acidified to form a salt to obtain the product.

purpose

widely used for topical anesthesia, infiltration anesthesia, conduction anesthesia, and epidural anesthesia. it is also an important drug in the treatment of sudden arrhythmias.